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Three spirostanol saponins and a flavane-O-glucoside from the fresh rhizomes of Tupistra chinensis.

Authors
Type
Published Article
Journal
Fitoterapia
0367-326X
Publisher
Elsevier
Publication Date
Volume
102
Pages
102–108
Identifiers
DOI: 10.1016/j.fitote.2015.02.008
PMID: 25707589
Source
Medline
Keywords
License
Unknown

Abstract

Four new compounds, including three new spirostanol saponins [tupistroside G-I (1-3)] and a new flavane-O-glucoside [tupichiside A (4)], together with ten known compounds, were isolated from the fresh rhizomes of Tupistra chinensis. The structures of the new compounds were elucidated by spectroscopic analysis and chemical evidence. All compounds were tested in vitro for their cytotoxic activities against the Human LoVo and BGC-823 cell lines, and six of them were found to possess potent cytotoxicity. Compounds 2, 8 and 9 showed significant cytotoxicity against the tested tumor cell lines with IC50 values ranging from 0.2 to 0.9μM.

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