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The three R's of lung health and disease: repair, remodeling, and regeneration.

Authors
  • Beers, Michael F
  • Morrisey, Edward E
Type
Published Article
Journal
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Publication Date
Jun 01, 2011
Volume
121
Issue
6
Pages
2065–2073
Identifiers
DOI: 10.1172/JCI45961
PMID: 21633173
Source
Medline
License
Unknown

Abstract

All tissues and organs can be classified according to their ability to repair and regenerate during adult homeostasis and after injury. Some exhibit a high rate of constant cell turnover, while others, such as the lung, exhibit only low-level cell regeneration during normal adult homeostasis but have the ability to rapidly regenerate new cells after injury. Lung regeneration likely involves both activation of progenitor cells as well as cell replacement through proliferation of remaining undamaged cells. The pathways and factors that control this process and its role in disease are only now being explored. In this Review, we will discuss the connection between pathways required for lung development and how the lung responds to injury and disease, with a particular emphasis on recent studies describing the role for the epithelium in repair and regeneration.

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