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Three Poliovirus Sequences in the Human Genome Associated With Colorectal Cancer.

Authors
  • Lehrer, Steven1
  • Rheinstein, Peter H2
  • 1 Radiation Oncology, Mount Sinai Medical Center, New York, NY, U.S.A. [email protected]
  • 2 Severn Health Solutions, Severna Park, MD, U.S.A.
Type
Published Article
Journal
Cancer Genomics & Proteomics
Publisher
International Institute of Anticancer Research
Publication Date
Jan 01, 2019
Volume
16
Issue
1
Pages
65–70
Identifiers
DOI: 10.21873/cgp.20112
PMID: 30587500
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

In a previous study we analyzed poliomyelitis incidence in US states, before the introduction of the polio vaccine. We noted an inverse correlation between polio incidence in US states, between 1937 and 1951, and colorectal cancer incidence (2005-2009). To further elucidate the role that poliovirus could play in colorectal cancer, the full human genome for poliovirus sequences was analyzed using the UCSC Genome Browser. BLAT, the Blast-Like Alignment Tool of the UCSC Genome Browser, was used to compare the poliovirus genome to the human genome. BLAT revealed three poliovirus sequences in three chromosomes: Chromosome 20p12.1 (MACROD2 gene), chromosome 1p13.3 (SLC25A24 gene), and chromosome 2p25.1. Poliovirus sequences in the human genome may contribute to programmed cell death and lysis of colorectal cancer cells. A recombinant poliovirus, incapable of reverting to neurovirulence, might be given orally at intervals as a colorectal cancer vaccine to prevent colorectal cancer. Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

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