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Three-dimensional structure of hyper-modified nucleoside Q located in the wobbling position of tRNA.

Authors
  • Yokoyama, S
  • Miyazawa, T
  • Iitaka, Y
  • Yamaizumi, Z
  • Kasai, H
  • Nishimura, S
Type
Published Article
Journal
Nature
Publication Date
Nov 01, 1979
Volume
282
Issue
5734
Pages
107–109
Identifiers
PMID: 388227
Source
Medline
License
Unknown

Abstract

The hyper-modified nucleoside Q (queuosine) is exclusively located in the wobbling position of anticodons of tRNATyr tRNAHis, tRNAAsn and tRNAAsp that recognise codons NAUC (ref. 1). Queuosine and its hexose-containing derivatives are widely distributed in microorganisms, animals and plants. We confirm here the chemical structure of queuosine as 7-(3, 4-trans-4, 5-cis-dihydroxy-1-cyclopenten-3-ylaminomethyl)-7-deazaguanosine (Fig. 1). The unique structural features of Q are the unusual cyclopentenediol side chain and the 7-deazaguanine ring. Queuosine is one of the most complicated modified nucleosides found thus far.

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