Affordable Access

Three-Dimensional Reconstruction of Erythrocyte in the Capillary

Authors
  • Fan, Yifang
  • Fan, Yubo
  • Li, Zhiyu
  • Lin, Wentao
  • Wei, Yuan
  • Zhong, Xing
  • Newman, Tony
  • Lv, Changsheng
  • Fan, Yuzhou
Type
Preprint
Publication Date
Jun 24, 2013
Submission Date
Jun 24, 2013
Identifiers
arXiv ID: 1306.5789
Source
arXiv
License
Yellow
External links

Abstract

The dynamic analysis of erythrocyte deformability is used as an important means for early diagnosis of blood diseases and blood rheology. Yet no effective method is available in terms of three-dimensional reconstruction of erythrocytes in a capillary. In this study, ultrathin serial sections of skeletal muscle tissue are obtained from the ultramicrotome, the tomographic images of an erythrocyte in a capillary are captured by the transmission electron microscope, and then a method to position and restore is devised to demonstrate the physiological relationship between two adjacent tomographic images of an erythrocyte. Both the modeling and the physical verification reveal that this method is effective, which means that it can be used to make three-dimensional reconstruction of an erythrocyte in a capillary. An example of reconstructed deformation of erythrocyte based on the serial ultrathin sections is shown at the end of this paper.

Report this publication

Statistics

Seen <100 times