The aim of this study was to retrospectively assess the osteosynthesis material-related morbidity rates of third-generation (3.0) slotplates, and to compare those with the previously researched second-generation (2.0) slotplates. In the 2.0 slotplate design, there were additional tabs in line with the vertical slotted screw hole; in between these tabs, the additional locking screw was placed. In the 3.0 slotplates, these tabs were replaced by a full screw hole for the locking screw, and the 3.0 slotplates are slightly broader than the 2.0 slotplates. Osteosynthesis material-related morbidity rates after Le Fort I-type, zygoma-valgisation, and chin osteotomies were assessed in a cohort receiving 3.0 slotplates in a tertiary care centre and compared to a previously analysed cohort receiving 2.0 slotplates in the same tertiary care centre. Medical records of 77 patients (101 surgeries) receiving 3.0 slotplates were reviewed. Plate infection and plate removal rates were low in the 3.0 slotplate group (2.6% (p = 0.123) and 3.9% (p = 0.103), respectively). No delayed union or non-union occurred in the 3.0 slotplate group. Comparing the morbidity rates with the 2.0 slotplate cohort did not yield any significant differences. Although there was a tendency towards better outcomes with 3.0 slotplates compared to the 2.0 slotplates, the outcome differences did not reach statistical significance. Copyright © 2020 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.