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Thiopentone-propofol hypnotic synergism in patients.

Authors
  • Naguib, M
  • Sari-Kouzel, A
Type
Published Article
Journal
British journal of anaesthesia
Publication Date
Jul 01, 1991
Volume
67
Issue
1
Pages
4–6
Identifiers
PMID: 1859757
Source
Medline
License
Unknown

Abstract

The hypnotic effects of thiopentone, propofol and their combination were studied in 120 unpremedicated ASA group I patients. The end-point for induction of anaesthesia was taken as inability to open the eyes to command 60 s after the end of injection. The dose-response curves were determined by probit analysis. Isobolographic and algebraic (fractional) analyses were used to assess quantitatively the combined hypnotic effect of thiopentone and propofol and to define the type of interaction between these two drugs. The interaction between thiopentone and propofol was found to be synergistic.

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