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Thioguanine nucleotides and thiopurine methyltransferase in immunobullous diseases: optimal levels as adjunctive tools for azathioprine monitoring.

Authors
  • el-Azhary, Rokea A
  • Farmer, Sara A
  • Drage, Lisa A
  • Rogers, Roy S 3rd
  • McEvoy, Marian T
  • Davis, Mark D P
  • Bridges, Alina G
  • Gibson, Lawrence E
Type
Published Article
Journal
Archives of Dermatology
Publisher
American Medical Association
Publication Date
Jun 01, 2009
Volume
145
Issue
6
Pages
644–652
Identifiers
DOI: 10.1001/archdermatol.2009.81
PMID: 19528417
Source
Medline
License
Unknown

Abstract

Optimal levels of 6-thioguanine nucleotide metabolites for disease remission in dermatology patients are 150 to 300 pmol/8 x 10(8) RBCs. High levels of the inactive metabolite 6-methylmercaptopurine and induction of thiopurine methyltransferase are associated with recalcitrant disease.

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