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Thiazide diuretics, endothelial function, and vascular oxidative stress.

Authors
  • Zhou, Ming-Sheng
  • Schulman, Ivonne Hernandez
  • Jaimes, Edgar A
  • Raij, Leopoldo
Type
Published Article
Journal
Journal of Hypertension
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Mar 01, 2008
Volume
26
Issue
3
Pages
494–500
Identifiers
DOI: 10.1097/HJH.0b013e3282f3e39d
PMID: 18300860
Source
Medline
License
Unknown

Abstract

This study demonstrates that thiazide diuretics do not reduce oxidative stress, improve endothelial function, or prevent the expression of pro-atherogenic molecules. We conclude that thiazide diuretics may not fully provide long-term global cardiovascular protection beyond lowering blood pressure.

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