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Thermospray liquid chromatography/mass spectrometry for the analysis of l-carnitine and its short-chain acyl derivatives

Authors
  • Yergey, Alfred L.
  • Liberato, Daniel J.
  • Millington, David S.
Type
Published Article
Journal
Analytical Biochemistry
Publisher
Elsevier BV
Publication Date
Jan 01, 1984
Volume
139
Issue
2
Pages
278–283
Identifiers
DOI: 10.1016/0003-2697(84)90003-4
Source
Elsevier
Keywords
License
Unknown

Abstract

A method utilizing thermospray high-performance liquid chromatography/mass spectrometry for the separation and direct analysis of carnitine, acetylcarnitine, and propionylcarnitine is described. On-column analysis of mixtures of the acylcarnitines with their corresponding stable, isotope-labeled analogs at nanomolar concentrations has indicated that isotope dilution assays can be applied towards the analysis of carnitine and short-chain acylcarnitines present in biological samples.

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