Affordable Access

deepdyve-link
Publisher Website

Thermo-sensitive composite hydrogels based on poloxamer 407 and alginate and their therapeutic effect in embolization in rabbit VX2 liver tumors.

Authors
  • Huang, Lili1
  • Shen, Ming1
  • Li, Rongxin1
  • Zhang, Xiangyu1
  • Sun, Ying1
  • Gao, Pei1
  • Fu, Hao1
  • Liu, Hongqiang2
  • He, Yang2
  • Du, Yuqing3
  • Cao, Jun2
  • Duan, Yourong1
  • 1 State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. , (China)
  • 2 Department of Interventional Oncology, Dahua Hospital, Xuhui District, Shanghai, China. , (China)
  • 3 Department of Interventional Radiology, Shanghai Pudong New District Punan Hospital, Shanghai, China. , (China)
Type
Published Article
Journal
Oncotarget
Publisher
"Impact Journals, LLC "
Publication Date
Nov 08, 2016
Volume
7
Issue
45
Pages
73280–73291
Identifiers
DOI: 10.18632/oncotarget.11789
PMID: 27602579
Source
Medline
Keywords
License
Unknown

Abstract

Interventional embolization therapy is an effective, most widely used method for inoperable liver tumors. Blood-vessel-embolic agents were essential in transarterial embolization (TAE). In this work, thermo-sensitive composite hydrogels based on poloxamer 407, sodium alginate, hydroxymethyl cellulose and iodixanol (PSHI), together with Ca2+ (PSHI-Ca2+) were prepared as liquid embolic agents for TAE therapy to liver cancer. With increasing temperature, PSHI exhibited two phase states: a flowing sol and a shrunken gel. Rheology tests showed good fluidity and excellent viscoelastic behavior with a gelation temperature (GT) of 26.5°C. The studies of erosion indicated that PSHI had calcium ion-related erosion characteristics and showed a slow erosion rate in an aqueous environment. When incubated with L929 cells, the thermo-sensitive composite hydrogels had low cytotoxicity in vitro. The results of analyzing the digital subtraction angiography and computed tomography images obtained from in vitro and in vivo assays indicated a good embolic effect in the renal arteries of normal rabbits. Angiography and histological studies on VX2 tumor-bearing rabbits indicated that PSHI-Ca2+ successfully occluded the tumors, including the peripheral vessels. In conclusion, PSHI-Ca2+ was a promising embolic agent for transarterial embolization therapy.

Report this publication

Statistics

Seen <100 times