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Thermoresponsive DNA by intercalation of dsDNA with oligoethylene-glycol-functionalized small-molecule intercalators

Authors
  • Bera, Debaditya
  • Verdonck, Lars
  • Glassner, Mathias
  • Madder, Annemieke
  • Hoogenboom, Richard
Publication Date
Jan 01, 2019
Source
Ghent University Institutional Archive
Keywords
Language
English
License
Unknown
External links

Abstract

Thermoresponsive polymeric materials are important building blocks for smart materials. In this work, the transformation of dsDNA into a thermoresponsive polymer is reported by intercalation of short, oligoethylene-glycol-modified proflavine intercalators. The thermoresponsiveness of the dsDNA-intercalator complex originates from the heating-induced dehydration of the ethylene glycol side chains, which leads to aggregation of the intercalated dsDNA. This work demonstrates the possibility of designing small-molecule intercalators to prepare thermoresponsive dsDNA complexes with tunable lower critical solution temperature behavior.

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