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Thermo-chemotherapy Induced miR-218 upregulation inhibits the invasion of gastric cancer via targeting Gli2 and E-cadherin.

Authors
  • Ruan, Qiang
  • Fang, Zhi-Yuan
  • Cui, Shu-Zhong
  • Zhang, Xiang-Liang
  • Wu, Yin-Bing
  • Tang, Hong-Sheng
  • Tu, Yi-Nuo
  • Ding, Yan
Type
Published Article
Journal
Tumor Biology
Publisher
SAGE Publications
Publication Date
Aug 01, 2015
Volume
36
Issue
8
Pages
5807–5814
Identifiers
DOI: 10.1007/s13277-015-3250-4
PMID: 25694126
Source
Medline
License
Unknown

Abstract

Thermo-chemotherapy has been proven to reduce the invasion capability of cancer cells. However, the molecular mechanism underlying this anti-invasion effect is still unclear. In this study, the role of thermo-chemotherapy in the inhibition of tumor invasion was studied. The results demonstrated that expression of miR-218 was downregulated in gastric cancer tissues, which had a positive correlation with tumor invasion and metastasis. In vitro thermo-chemotherapy increased miR-218 expression in SGC7901 cells and inhibited both proliferation and invasion of cancer cells. Gli2 was identified as a downstream target of miR-218, and its expression was negatively regulated by miR-218. The thermo-chemotherapy induced miR-218 upregulation was also accompanied by increasing of E-cadherin expression. In conclusion, the present study indicates that thermo-chemotherapy can effectively decrease the invasion capability of cancer cells and increase cell-cell adhesion. miR-218 and its downstream target Gli2, as well as E-cadherin, participate in the anti-invasion process.

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