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Thermal, spectral and biological characterisation of copper(II) complexes with isoniazid-based hydrazones

Authors
  • Zarafu, Irina1
  • Badea, Mihaela2
  • Ioniţă, Gabriela3
  • Chifiriuc, Mariana Carmen4, 5
  • Bleotu, Coralia6
  • Popa, Marcela4, 5
  • Ioniţă, Petre1
  • Tatibouët, Arnaud7
  • Olar, Rodica2
  • 1 University of Bucharest, Department of Organic Chemistry, Faculty of Chemistry, 90-92 Panduri Str., 050663 Sector 5, Bucharest, Romania , Bucharest (Romania)
  • 2 University of Bucharest, Department of Inorganic Chemistry, Faculty of Chemistry, 90-92 Panduri Str., 050663 Sector 5, Bucharest, Romania , Bucharest (Romania)
  • 3 Romanian Academy, “Ilie Murgulescu” Physical Chemistry Institute, 202 Splaiul Independentei, Bucharest, 060021, Romania , Bucharest (Romania)
  • 4 University of Bucharest, Department of Microbiology, Faculty of Biology, 1-3 Aleea Portocalilor St, Bucharest, 60101, Romania , Bucharest (Romania)
  • 5 ICUB, Research Institute of the University of Bucharest, Splaiul Independentei 91-95, Bucharest, Romania , Bucharest (Romania)
  • 6 Stefan S Nicolau Institute of Virology, 285 Mihai Bravu Ave, Bucharest, Romania , Bucharest (Romania)
  • 7 University of Orleans, ICOA-UMR7311, CNRS, Orleans, France , Orleans (France)
Type
Published Article
Journal
Journal of Thermal Analysis and Calorimetry
Publisher
Springer Netherlands
Publication Date
Oct 27, 2018
Volume
136
Issue
5
Pages
1977–1987
Identifiers
DOI: 10.1007/s10973-018-7853-z
Source
Springer Nature
Keywords
License
Yellow

Abstract

A series of complexes [Cu(L)(CH3COO)2]·nH2O (L: isonicotinic acid 2-(2-hydroxy-8-substituted-tricyclo[7.3.1.02.7]tridec-13-ylidene)-hydrazones) were synthesised and characterised. The features of complexes have been assigned from microanalytical data, ESI–MS, IR, UV–Vis–NIR and EPR spectra, as well as thermal analysis. The ligands (hydrazones and acetate) act as chelate in the octahedral distorted complexes of Cu(II). The thermal analysis evidenced complex thermal transformations such as thermolises and oxidative degradation of hydrazone moiety as well as acetate into carbonate transformation, followed by carbonate decomposition up to CuO. The complexes were evaluated for their interaction with microbial and immortalised human cells, in order to formulate some potential biomedical applications, beyond the antimycobacterial activity.

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