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Thermal migration of molecular lipid films as a contactless fabrication strategy for lipid nanotube networks.

Authors
Type
Published Article
Journal
Lab on a Chip
1473-0189
Publisher
The Royal Society of Chemistry
Publication Date
Volume
13
Issue
19
Pages
3822–3826
Identifiers
DOI: 10.1039/c3lc50391g
PMID: 23903381
Source
Medline
License
Unknown

Abstract

We demonstrate the contactless generation of lipid nanotube networks by means of thermally induced migration of flat giant unilamellar vesicles (FGUVs), covering micro-scale areas on oxidized aluminum surfaces. A temperature gradient with a reach of 20 μm was generated using a focused IR laser, leading to a surface adhesion gradient, along which FGUVs could be relocated. We report on suitable lipid-substrate combinations, highlighting the critical importance of the electrostatic interactions between the engineered substrate and the membrane for reversible migration of intact vesicles.

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