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Therapeutics for filovirus infection: traditional approaches and progress towards in silico drug design.

Authors
Type
Published Article
Journal
Expert Opinion on Drug Discovery
1746-045X
Publisher
Informa UK (Taylor & Francis)
Publication Date
Volume
7
Issue
10
Pages
935–954
Identifiers
PMID: 22873527
Source
Medline
License
Unknown

Abstract

To discover novel therapeutics with potent efficacy using sophisticated computational methods, more high-resolution crystal structures of filovirus proteins and more details about the protein functions and host interaction will be required. Current compound screening efforts are finding active antiviral compounds, but an emphasis on discovery research to investigate protein structures and functions enabling in silico drug design would provide another avenue for finding antiviral molecules. Additionally, targeting of protein-protein interactions may be a future avenue for drug discovery since disrupting catalytic sites may not be possible for all proteins.

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