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Therapeutically Targeting Tumor Necrosis Factor-α/Sphingosine-1-Phosphate Signaling Corrects Myogenic Reactivity in Subarachnoid Hemorrhage.

Authors
Type
Published Article
Journal
Stroke
1524-4628
Publisher
Ovid Technologies Wolters Kluwer -American Heart Association
Publication Date
Volume
46
Issue
8
Pages
2260–2270
Identifiers
DOI: 10.1161/STROKEAHA.114.006365
PMID: 26138121
Source
Medline
Keywords
License
Unknown

Abstract

Vascular smooth muscle cell TNFα and sphingosine-1-phosphate signaling significantly enhance cerebral artery tone in SAH; anti-TNFα and anti-sphingosine-1-phosphate treatment may significantly improve clinical outcome.

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