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Therapeutically Targeting Tumor Necrosis Factor-α/Sphingosine-1-Phosphate Signaling Corrects Myogenic Reactivity in Subarachnoid Hemorrhage.

Authors
  • Yagi, Kenji
  • Lidington, Darcy
  • Wan, Hoyee
  • Fares, Jessica C
  • Meissner, Anja
  • Sumiyoshi, Manabu
  • Ai, Jinglu
  • Foltz, Warren D
  • Nedospasov, Sergei A
  • Offermanns, Stefan
  • Nagahiro, Shinji
  • Macdonald, R Loch
  • Bolz, Steffen-Sebastian
Type
Published Article
Journal
Stroke
Publisher
Ovid Technologies Wolters Kluwer -American Heart Association
Publication Date
Aug 01, 2015
Volume
46
Issue
8
Pages
2260–2270
Identifiers
DOI: 10.1161/STROKEAHA.114.006365
PMID: 26138121
Source
Medline
Keywords
License
Unknown

Abstract

Vascular smooth muscle cell TNFα and sphingosine-1-phosphate signaling significantly enhance cerebral artery tone in SAH; anti-TNFα and anti-sphingosine-1-phosphate treatment may significantly improve clinical outcome.

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