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Therapeutic vaccine against IL-1 beta improved glucose control in a mouse model of type 2 diabetes

Authors
  • Zhang, Yue
  • Yu, Xiao-lin
  • Zha, Jun
  • Mao, Li-zhen
  • Chai, Jia-qian
  • Liu, Rui-tian
Publication Date
Jan 01, 2018
Source
Institutional Repository of Institute of Process Engineering, CAS (IPE-IR)
Keywords
License
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Abstract

Aims: Inflammation is strongly associated with the mechanism of beta-cell failure in type 2 diabetes mellitus (T2DM). Blockade of the key proinflammatory cytokine IL-1 beta has been implicated as a promising therapeutic strategy for the prevention and treatment of type 2 diabetes. In this study, we developed an IL-1 beta-targeted therapeutic vaccine consisting of an IL-1 beta epitope peptide (A1 beta) and assessed its efficacy on a diabetic KK-A(y) mouse model.

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