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Therapeutic recombinant murine activated protein C attenuates pulmonary coagulopathy and improves survival in murine pneumococcal pneumonia.

Authors
  • Schouten, Marcel
  • van 't Veer, Cornelis
  • van den Boogaard, Florry E
  • Gerlitz, Bruce
  • Grinnell, Brian W
  • Roelofs, Joris J T H
  • Levi, Marcel
  • van der Poll, Tom
Type
Published Article
Journal
The Journal of Infectious Diseases
Publisher
Oxford University Press
Publication Date
Nov 15, 2010
Volume
202
Issue
10
Pages
1600–1607
Identifiers
DOI: 10.1086/656787
PMID: 20925531
Source
Medline
License
Unknown

Abstract

Rm-APC inhibits pulmonary activation of coagulation and, when added to antibiotic therapy, improves survival in murine pneumococcal pneumonia.

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