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Therapeutic monitoring of continuous infusion etoposide in small-cell lung cancer.

Authors
  • Joel, S P
  • Ellis, P
  • O'Byrne, K
  • Papamichael, D
  • Hall, M
  • Penson, R
  • Nicholls, S
  • O'Donnell, C
  • Constantinou, A
  • Woodhull, J
  • Nicholson, M
  • Smith, I
  • Talbot, D
  • Slevin, M
Type
Published Article
Journal
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Publication Date
Jun 01, 1996
Volume
14
Issue
6
Pages
1903–1912
Identifiers
PMID: 8656259
Source
Medline
License
Unknown

Abstract

Therapeutic monitoring of infusional etoposide is feasible and dramatically reduces interpatient pharmacokinetic variability. Although this was a small nonrandomized trial, the observation of different hematologic toxicity at the two starting concentrations but similar antitumor activity further suggests that these effects may be associated with different plasma etoposide concentrations.

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