Affordable Access

deepdyve-link
Publisher Website

The therapeutic importance of acid-base balance

Authors
  • Quade, Bianca N.1
  • Parker, Mark D.1, 2, 3
  • Occhipinti, Rossana4
  • 1 Department of Physiology and Biophysics, The State University of New York, The University at Buffalo, Buffalo, NY 14203, USA
  • 2 Department of Ophthalmology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA
  • 3 State University of New York Eye Institute, University at Buffalo, The State University of New York, Buffalo, NY, USA
  • 4 Department of Physiology and Biophysics, Case Western Reserve University, School of Medicine, Cleveland, OH 44106, USA
Type
Published Article
Journal
Biochemical pharmacology
Publisher
New York, NY : Elsevier Science Inc
Publication Date
Oct 09, 2020
Volume
183
Pages
114278–114278
Identifiers
DOI: 10.1016/j.bcp.2020.114278
PMID: 33039418
PMCID: PMC7544731
Source
PubMed Central
Keywords
Disciplines
  • Perspective
License
Unknown

Abstract

Baking soda and vinegar have been used as home remedies for generations and today we are only a mouse-click away from claims that baking soda, lemon juice, and apple cider vinegar are miracles cures for everything from cancer to COVID-19. Despite these specious claims, the therapeutic value of controlling acid-base balance is indisputable and is the basis of Food and Drug Administration-approved treatments for constipation, epilepsy, metabolic acidosis, and peptic ulcers. In this narrative review, we present evidence in support of the current and potential therapeutic value of countering local and systemic acid-base imbalances, several of which do in fact involve the administration of baking soda (sodium bicarbonate). Furthermore, we discuss the side effects of pharmaceuticals on acid-base balance as well as the influence of acid-base status on the pharmacokinetic properties of drugs. Our review considers all major organ systems as well as information relevant to several clinical specialties such as anesthesiology, infectious disease, oncology, dentistry, and surgery.

Report this publication

Statistics

Seen <100 times