Affordable Access

Access to the full text

Therapeutic Efficacy of Artificial Skin Produced by 3D Bioprinting

Authors
  • jang, kwang-sik
  • park, soon-jung
  • choi, jong-jin
  • kim, ha-na
  • shim, kyung-mi
  • kim, mi-jeong
  • jang, il-ho
  • jin, song-wan
  • kang, seong-soo
  • kim, se-eun
  • moon, sung-hwan
Publication Date
Sep 09, 2021
Identifiers
DOI: 10.3390/ma14185177
OAI: oai:mdpi.com:/1996-1944/14/18/5177/
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

The skin protects the body from external barriers. Certain limitations exist in the development of technologies to rapidly prepare skin substitutes that are therapeutically effective in surgeries involving extensive burns and skin transplantation. Herein, we fabricated a structure similar to the skin layer by using skin-derived decellularized extracellular matrix (dECM) with bioink, keratinocytes, and fibroblasts using 3D-printing technology. The therapeutic effects of the produced skin were analyzed using a chimney model that mimicked the human wound-healing process. The 3D-printed skin substitutes exhibited rapid re-epithelialization and superior tissue regeneration effects compared to the control group. These results are expected to aid the development of technologies that can provide customized skin-replacement tissues produced easily and quickly via 3D-printing technology to patients.

Report this publication

Statistics

Seen <100 times