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Therapeutic Effects of Bacteriophage Cpl-1 Lysin against Streptococcus pneumoniae Endocarditis in Rats

Authors
  • J. M. Entenza
  • J. M. Loeffler
  • D. Grandgirard
  • V. A. Fischetti
  • P. Moreillon
Publisher
American Society for Microbiology
Publication Date
Nov 01, 2005
Source
PMC
Keywords
Disciplines
  • Biology
License
Unknown

Abstract

Cpl-1, a pneumococcal phage lytic enzyme, was tested in rats with experimental endocarditis due to Streptococcus pneumoniae WB4. High-dose regimen Cpl-1 eliminated pneumococci from blood within 30 min and decreased bacterial titers in vegetations (>4 log10 CFU/g) within 2 h. Rapid bacterial lysis induced by Cpl-1 treatment increased cytokine secretion noticeably.

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