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Therapeutic effects of naringin on degenerative human nucleus pulposus cells for discogenic low back pain.

Authors
  • Li, Nianhu1
  • Whitaker, Camden2
  • Xu, Zhanwang3
  • Heggeness, Michael4
  • Yang, Shang-You5
  • 1 Department of Orthopedics, University of Kansas School of Medicine-Wichita, 929 N Saint Francis St, Wichita, KS, USA; Department of Orthopaedic Surgery, Affiliated Hospital to Shandong University of Traditional Chinese Medicine, 42 Wenhua West Road, Jinan, China. , (China)
  • 2 Department of Orthopedics, University of Kansas School of Medicine-Wichita, 929 N Saint Francis St, Wichita, KS, USA.
  • 3 Department of Orthopaedic Surgery, Affiliated Hospital to Shandong University of Traditional Chinese Medicine, 42 Wenhua West Road, Jinan, China. , (China)
  • 4 Department of Orthopedics, University of Kansas School of Medicine-Wichita, 929 N Saint Francis St, Wichita, KS, USA; Robert J. Dole Veterans Administration Hospital Center, 5500 E. Kellogg, Wichita, KS, USA.
  • 5 Department of Orthopedics, University of Kansas School of Medicine-Wichita, 929 N Saint Francis St, Wichita, KS, USA; Department of Biological Sciences, Wichita State University, 1845 Fairmount Street, Wichita, KS, USA. Electronic address: [email protected].
Type
Published Article
Journal
The spine journal : official journal of the North American Spine Society
Publication Date
October 2016
Volume
16
Issue
10
Pages
1231–1237
Identifiers
DOI: 10.1016/j.spinee.2016.05.007
PMID: 27208552
Source
Medline
Keywords
License
Unknown

Abstract

Naringin effectively promotes the proliferation of degenerative human NP cells and improves the recuperation of the cells from degeneration by increasing expression of aggrecan, BMP-2, and Sox6 while inhibiting the expression of TNF-α and MMP3. This study suggests that naringin may represent an alternative therapeutic agent for disc degeneration.

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