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Therapeutic Effect of Vinorine on Sciatic Nerve Injured Rat.

Authors
  • Guo, Dongdong1
  • Lu, Xingang2
  • Xu, Xiaoli2
  • Gou, Haixin2
  • Wang, Zhiqian3
  • Cao, Yi4
  • Luo, Xingjing5
  • 1 Department of Anesthesia, Children's Hospital, Fudan University, Shanghai, 201102, People's Republic of China. , (China)
  • 2 Department of Traditional Chinese Medicine, Huadong Hospital, Fudan University, Shanghai, 200040, People's Republic of China. , (China)
  • 3 Department of Acupuncture, Pengpu Community Hospital, Shanghai, 200072, People's Republic of China. , (China)
  • 4 Department of Geriatrics, Baoshan Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201999, People's Republic of China. , (China)
  • 5 Department of Anesthesia, Children's Hospital, Fudan University, Shanghai, 201102, People's Republic of China. [email protected] , (China)
Type
Published Article
Journal
Neurochemical Research
Publisher
Springer-Verlag
Publication Date
Feb 01, 2018
Volume
43
Issue
2
Pages
375–386
Identifiers
DOI: 10.1007/s11064-017-2432-4
PMID: 29119332
Source
Medline
Keywords
License
Unknown

Abstract

Vinorine is a monoterpenoid indole alkaloid, a type of natural alkaloids. Growing reports exhibited the numerous pharmacology activities of vinorine such as anti-inflammation, anti-bacterial and anti-tumor. In this study, the effect of vinorine injection (7.5, 15 and 30 mg/kg) on motor function, sensation and nerve regeneration in sciatic nerve crush injury rat was investigated. The results of behavioral analysis, electrophysiological analysis and muscle histological analysis suggested that vinorine promoted the motor function recovery after sciatic nerve injury. The results of mechanical withdrawal thresholds assay and hot plate test demonstrated that vinorine improved the sensation recovery after sciatic nerve injury. The results of Fluoro-gold retrograde labeling, transmission electron microscope assay, toluidine blue and HE staining showed that vinorine attenuated the nerve damage caused by sciatic nerve injury and promoted the nerve regeneration. Furthermore, nerve growth factor (NGF) and its downstream extracellular signal-regulated kinase (ERK) signaling pathway participated in the neuro-recovery effect of vinorine after crush. In conclusion, vinorine treatment accelerated the sciatic nerve regeneration, motor function recovery and sensation recovery after crush injury via regulation of NGF and ERK activity. These results suggested that vinorine is a promising agent for never injury therapy.

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