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Therapeutic Effect of Vinorine on Sciatic Nerve Injured Rat

Authors
  • Guo, Dongdong1
  • Lu, Xingang2
  • Xu, Xiaoli2
  • Gou, Haixin2
  • Wang, Zhiqian3
  • Cao, Yi4
  • Luo, Xingjing1
  • 1 Fudan University, Department of Anesthesia, Children’s Hospital, Shanghai, 201102, People’s Republic of China , Shanghai (China)
  • 2 Fudan University, Department of Traditional Chinese Medicine, Huadong Hospital, Shanghai, 200040, People’s Republic of China , Shanghai (China)
  • 3 Pengpu Community Hospital, Department of Acupuncture, Shanghai, 200072, People’s Republic of China , Shanghai (China)
  • 4 Shanghai University of Traditional Chinese Medicine, Department of Geriatrics, Baoshan Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai, 201999, People’s Republic of China , Shanghai (China)
Type
Published Article
Journal
Neurochemical Research
Publisher
Springer-Verlag
Publication Date
Nov 08, 2017
Volume
43
Issue
2
Pages
375–386
Identifiers
DOI: 10.1007/s11064-017-2432-4
Source
Springer Nature
Keywords
License
Yellow

Abstract

Vinorine is a monoterpenoid indole alkaloid, a type of natural alkaloids. Growing reports exhibited the numerous pharmacology activities of vinorine such as anti-inflammation, anti-bacterial and anti-tumor. In this study, the effect of vinorine injection (7.5, 15 and 30 mg/kg) on motor function, sensation and nerve regeneration in sciatic nerve crush injury rat was investigated. The results of behavioral analysis, electrophysiological analysis and muscle histological analysis suggested that vinorine promoted the motor function recovery after sciatic nerve injury. The results of mechanical withdrawal thresholds assay and hot plate test demonstrated that vinorine improved the sensation recovery after sciatic nerve injury. The results of Fluoro-gold retrograde labeling, transmission electron microscope assay, toluidine blue and HE staining showed that vinorine attenuated the nerve damage caused by sciatic nerve injury and promoted the nerve regeneration. Furthermore, nerve growth factor (NGF) and its downstream extracellular signal-regulated kinase (ERK) signaling pathway participated in the neuro-recovery effect of vinorine after crush. In conclusion, vinorine treatment accelerated the sciatic nerve regeneration, motor function recovery and sensation recovery after crush injury via regulation of NGF and ERK activity. These results suggested that vinorine is a promising agent for never injury therapy.

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