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Therapeutic effect of mesenchymal stem cells in an animal model of Alzheimer's disease evaluated by β-amyloid positron emission tomography imaging.

Authors
  • Park, Bok-Nam1
  • Kim, Jang-Hee2
  • Lim, Tae Sung3
  • Park, So Hyun2
  • Kim, Tae-Gyu2
  • Yoon, Bok Seon4
  • Son, Keoung Sun4
  • Yoon, Joon-Kee1
  • An, Young-Sil1
  • 1 Department of Nuclear Medicine and Molecular Imaging, School of Medicine, Ajou University, Suwon, South Korea. , (North Korea)
  • 2 Department of Pathology, School of Medicine, Ajou University, Suwon, South Korea. , (North Korea)
  • 3 Department of Neurology, School of Medicine, Ajou University, Suwon, South Korea. , (North Korea)
  • 4 Neuroscience Graduate Program, Biomedical Sciences, School of Medicine, Ajou University, Suwon, South Korea. , (North Korea)
Type
Published Article
Journal
Australian & New Zealand Journal of Psychiatry
Publisher
SAGE Publications
Publication Date
Sep 01, 2020
Volume
54
Issue
9
Pages
883–891
Identifiers
DOI: 10.1177/0004867420917467
PMID: 32436738
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

We evaluated the effects of bone marrow-derived mesenchymal stem cells in a model of Alzheimer's disease using serial [18F]Florbetaben positron emission tomography. 3xTg Alzheimer's disease mice were treated with intravenously injected bone marrow-derived mesenchymal stem cells, and animals without stem cell therapy were used as controls. Serial [18F]Florbetaben positron emission tomography was performed after therapy. The standardized uptake value ratio was measured as the cortex standardized uptake value divided by the cerebellum standardized uptake value. Memory function and histological changes were observed using the Barnes maze test and β-amyloid-reactive cells. Standardized uptake value ratio decreased significantly from day 14 after stem cell administration in the bone marrow-derived mesenchymal stem cells-treated group (n = 28). In contrast, there was no change in the ratio in control mice (n = 25) at any time point. In addition, mice that received bone marrow-derived mesenchymal stem cell therapy also exhibited significantly better memory function and less β-amyloid-immunopositive plaques compared to controls. The therapeutic effect of intravenously injected bone marrow-derived mesenchymal stem cells in a mouse model of Alzheimer's disease was confirmed by β-amyloid positron emission tomography imaging, memory functional studies and histopathological evaluation.

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