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No Therapeutic Effect of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Retreatment Despite T790M Disappearance: Case Report of 3 Cases

Authors
  • Kodama, Tatsuya
  • Watanabe, Keisuke
  • Shinkai, Masaharu
  • Kaneko, Takeshi
Type
Published Article
Journal
Chemotherapy
Publisher
S. Karger AG
Publication Date
Aug 24, 2018
Volume
63
Issue
4
Pages
198–202
Identifiers
DOI: 10.1159/000491937
PMID: 30145590
Source
Karger
Keywords
License
Green
External links

Abstract

Background: T790M is a major cause of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) resistance, but the clinical significance of T790M disappearance is unknown. Case Report: We report 3 cases of pulmonary adenocarcinoma which did not respond to EGFR-TKI retreatment even with T790M disappearance. T790M mutations were detected in the pleural effusions after the tumors had acquired EGFR-TKI resistance. T790M mutations disappeared from cancer cells in the pleural effusion after a break from the treatment drug and cytotoxic agent administration. However, no therapeutic effect was obtained despite EGFR-TKI reinitiation. Conclusions: Responsiveness to EGFR-TKI might not be restored in some cases, although the disappearance of T790M mutations is confirmed.

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