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Therapeutic drug monitoring of A77 1726, the active metabolite of leflunomide: serum concentrations predict response to treatment in patients with rheumatoid arthritis.

Authors
  • van Roon, E N
  • Jansen, T L T A
  • van de Laar, M A F J
  • Janssen, M
  • Yska, J P
  • Keuper, R
  • Houtman, P M
  • Brouwers, J R B J
Type
Published Article
Journal
Annals of the rheumatic diseases
Publication Date
Apr 01, 2005
Volume
64
Issue
4
Pages
569–574
Identifiers
PMID: 15345501
Source
Medline
License
Unknown

Abstract

A77 1726 steady state serum concentrations show a relation with DAS28 response. Determination of serum A77 1726 concentrations in patients with insufficient response to treatment may help when decisions have to be made about continuation of treatment or dose adjustment.

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