Affordable Access

deepdyve-link
Publisher Website

Therapeutic depletion of monocyte-derived cells protects from long-term axonal loss in experimental autoimmune encephalomyelitis.

Authors
Type
Published Article
Journal
Journal of Neuroimmunology
Publisher
Elsevier
Volume
290
Pages
36–36
Identifiers
DOI: 10.1016/j.jneuroim.2015.11.004
Source
Soulika Lab - UC Davis dermatology-ucdavis
License
Unknown

Abstract

Studies in multiple sclerosis and its animal model experimental autoimmune encephalomyelitis (EAE) suggest that peripheral monocyte-derived cells (MDCs) are instrumental for disease initiation. MDCs, however, are plastic, and may exert various functions once in the central nervous system (CNS) for prolonged periods. Furthermore, the long-term effect of MDC depletion on continuing axon loss is not known. We show that long-lasting depletion of MDCs, after onset of EAE clinical deficits, is accompanied by decreased CNS infiltration by pathogenic T lymphocytes. Although this treatment does not reverse clinical disease, it prevents worsening of neurological deficits and long-term axonal loss.

Report this publication

Statistics

Seen <100 times