Affordable Access

deepdyve-link
Publisher Website

Theranostic magnetoliposomes coated by carboxymethyl dextran with controlled release by low-frequency alternating magnetic field.

Authors
  • Guo, Hongyan
  • Chen, Wansong
  • Sun, Xiaoyi
  • Liu, You-Nian
  • Li, Juan
  • Wang, Jianxiu
Type
Published Article
Journal
Carbohydrate Polymers
Publisher
Elsevier
Publication Date
Mar 15, 2015
Volume
118
Pages
209–217
Identifiers
DOI: 10.1016/j.carbpol.2014.10.076
PMID: 25542126
Source
Medline
Keywords
License
Unknown

Abstract

The aim of this work was to construct carboxymethyl dextran (CMD)-coated magnetoliposomes (MLs), another stealth MLs alternative to PEGylated MLs, for theranostic application. Particularly, the on-demand release of CMD-MLs under low-frequency alternating magnetic field (LF-AMF) was studied. We found that as-prepared MLs exhibited good stability and high drug loading ability for doxorubicin (DOX). Cytotoxicity assay against human neuroblastoma SH-SY5Y cells showed that the DOX-loaded CMD-MLs were less toxic than free DOX due to the sustained release of DOX. However, the release of DOX-loaded CMD-MLs was enhanced by low-frequency alternating magnetic field without hyperthermia generation. The MLs also acted as an efficient T2-weighted contrast agent during in vitro MRI measurements. The above results provide useful information on in vivo diagnostic/therapeutic efficacy of DOX-loaded CMD-MLs for some cancers, such as brain cancers.

Report this publication

Statistics

Seen <100 times