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Theoretical insights into bacterial chemotaxis.

Authors
  • Tindall, Marcus J
  • Gaffney, Eamonn A
  • Maini, Philip K
  • Armitage, Judith P
Type
Published Article
Journal
Wiley Interdisciplinary Reviews Systems Biology and Medicine
Publisher
Wiley (John Wiley & Sons)
Publication Date
Jan 01, 2012
Volume
4
Issue
3
Pages
247–259
Identifiers
DOI: 10.1002/wsbm.1168
PMID: 22411503
Source
Medline
License
Unknown

Abstract

Research into understanding bacterial chemotactic systems has become a paradigm for Systems Biology. Experimental and theoretical researchers have worked hand-in-hand for over 40 years to understand the intricate behavior driving bacterial species, in particular how such small creatures, usually not more than 5 µm in length, detect and respond to small changes in their extracellular environment. In this review we highlight the importance that theoretical modeling has played in providing new insight and understanding into bacterial chemotaxis. We begin with an overview of the bacterial chemotaxis sensory response, before reviewing the role of theoretical modeling in understanding elements of the system on the single cell scale and features underpinning multiscale extensions to population models.

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