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[Theophylline--contemporary views on cellular mechanism of action].

Authors
  • Chorostowska-Wynimko, J
Type
Published Article
Journal
Postȩpy higieny i medycyny doświadczalnej
Publication Date
Jan 01, 2000
Volume
54
Issue
6
Pages
867–877
Identifiers
PMID: 11227382
Source
Medline
License
Unknown

Abstract

Theophylline has been used in the treatment of obstructive pulmonary diseases since 30s. However, its mechanism of action is still poorly defined. Up to now, its several different actions on the cellular levels are known or hypothesised including most important--inhibition of phosphodiesterase isoenzymes and antagonism of adenosine, as well as enhancement of catecholamine secretion and modulation of calcium ions fluxes. Author reviews all of the proposed theories, outlining existing arguments for and against.

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