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The yeast metacaspase is implicated in oxidative stress response in frataxin-deficient cells.

Authors
  • Sophie Lefevre
  • Dominika Sliwa
  • Françoise Auchère
  • Caroline Brossas
  • Christoph Ruckenstuhl
  • Nicole Boggetto
  • Emmanuel Lesuisse
  • Frank Madeo
  • Jean-Michel Camadro
  • Renata Santos
Identifiers
DOI: 10.1016/j.febslet.2011.12.002
Source
CdV-UPMC
License
Unknown

Abstract

Friedreich ataxia is the most common recessive neurodegenerative disease and is caused by reduced expression of mitochondrial frataxin. Frataxin depletion causes impairment in iron-sulfur cluster and heme biosynthesis, disruption of iron homeostasis and hypersensitivity to oxidants. Currently no pharmacological treatment blocks disease progression, although antioxidant therapies proved to benefit patients. We show that sensitivity of yeast frataxin-deficient cells to hydrogen peroxide is partially mediated by the metacaspase. Metacaspase deletion in frataxin-deficient cells results in recovery of antioxidant capacity and heme synthesis. In addition, our results suggest that metacaspase is associated with mitochondrial respiration, intracellular redox control and genomic stability. Copyright © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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