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The trappist's approach to pathfinding: elucidating brain wiring using secretory-trap mutagenesis

Authors
  • Andrew J Furley
Publisher
BioMed Central
Publication Date
Jan 01, 2001
Source
PMC
Keywords
Disciplines
  • Medicine
License
Unknown

Abstract

A key problem in using genetics to dissect the wiring of the mammalian brain lies in discovering which of the billions of neural connections have been disrupted by a particular mutation. A novel gene-trap approach targets the genes involved in brain wiring and labels the axons of neurons expressing those genes, enabling the effects of mutations to be observed directly.

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