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The role of endothelin-1 in hyperoxia-induced lung injury in mice

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BioMed Central
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PMC
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  • Research

Abstract

1465-9921-7-45.fm ral ss BioMed CentRespiratory Research Open AcceResearch The role of endothelin-1 in hyperoxia-induced lung injury in mice Walid Habre1, Ferenc Peták*2, Isabelle Ruchonnet-Metrailler3, Yves Donati3, Jean-Francois Tolsa4, Eniko Lele2, Gergely Albu1, Morice Beghetti5 and Constance Barazzone-Argiroffo3,6 Address: 1Pediatric Anesthesia Unit, Geneva Children's Hospital, University Hospitals of Geneva, 6, Rue Willy Donze, CH-1205, Geneva, Switzerland, 2Department of Medical Informatics and Engineering, University of Szeged, Koranyi fasor 9, H-6720, Szeged, Hungary, 3Department of Immunology and Pathology, University of Geneva, 1 rue Michel-Servet, CH-1211, Geneva 14, Switzerland, 4Department of Pediatrics, University Hospital of Lausanne, Rue du Bugnon 46, 1011 Lausanne, Switzerland, 5Pediatric Cardiology Unit, Department of Pediatrics, Geneva Children's Hospital, 6, Rue Willy Donze, CH-1205, Geneva, Switzerland and 6Pediatric Pulmonology Unit, Department of Pediatrics, Geneva Children's Hospital, 6, Rue Willy Donze, CH-1205, Geneva, Switzerland Email: Walid Habre - [email protected]; Ferenc Peták* - [email protected]; Isabelle Ruchonnet- Metrailler - [email protected]; Yves Donati - [email protected]; Jean-Francois Tolsa - [email protected]; Eniko Lele - [email protected]; Gergely Albu - [email protected]; Morice Beghetti - [email protected]; Constance Barazzone-Argiroffo - [email protected] * Corresponding author Abstract Background: As prolonged hyperoxia induces extensive lung tissue damage, we set out to investigate the involvement of endothelin-1 (ET-1) receptors in these adverse changes. Methods: Experiments were performed on four groups of mice: control animals kept in room air and a group of mice exposed to hyperoxia for 60 h were not subjected to ET-1 receptor blockade, whereas the dual ETA/ETB-receptor blocker tezosantan (TEZ) was administered via an intraperit

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