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The role of complement, antibody, and tumor necrosis factor alpha in the killing of Plasmodium falciparum by the monocytic cell line THP-1.

Authors
  • L M Kumaratilake
  • A Ferrante
  • T Jaeger
  • S D Morris-Jones
Publication Date
Dec 01, 1997
Source
PMC
Keywords
License
Unknown

Abstract

Killing of Plasmodium falciparum blood forms by the differentiated human myelomonocytic THP-1Mo cell line was studied by a radiometric assay. Results showed that parasite killing was promoted by complement, antimalarial antibody, and the cytokines tumor necrosis factor alpha and gamma interferon. Differentiated THP-1Mo appears to be a useful monocytic cell line for the study of mechanisms of immunity to Plasmodium.

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