Affordable Access

deepdyve-link
Publisher Website

The RASSF proteins in cancer; from epigenetic silencing to functional characterization.

Authors
  • Richter, Antje M1
  • Pfeifer, Gerd P
  • Dammann, Reinhard H
  • 1 Institute for Genetics, Justus Liebig University Giessen, Heinrich-Buff-Ring 58-62, D-35392 Giessen, Germany. , (Germany)
Type
Published Article
Journal
Biochimica et Biophysica Acta
Publisher
Elsevier
Publication Date
Dec 01, 2009
Volume
1796
Issue
2
Pages
114–128
Identifiers
DOI: 10.1016/j.bbcan.2009.03.004
PMID: 19344752
Source
Medline
Language
English
License
Unknown

Abstract

The Ras-Association Domain Family (RASSF) comprises ten members, termed RASSF1 to RASSF10. RASSF1 to RASSF6 harbor a C-terminal Ras-association (RA) domain and RASSF7 to RASSF10 contain an N-terminal RA domain. Interestingly, it was observed that in various tumor types distinct RASSFs transcripts (e.g. RASSF1A and RASSF2A) are missing due to hypermethylation of their CpG island promoter. Since methylation of the RASSF1A promoter is described as an early and frequent event in tumorigenesis, RASSF1A could serve as a useful diagnostic marker in cancer screens. RASSFs are implicated in various cellular mechanisms including apoptosis, cell cycle control and microtubule stabilization, though little is known about the underlying mechanisms. Tumor suppressing functions were reported for several members. Here we review the current literature on RASSF members focusing on structural, functional and epigenetic aspects. Characterizing the cellular mechanisms that regulate the signaling pathways RASSFs are involved in, could lead to a deeper understanding of tumor development and, furthermore, to new strategies in cancer treatment.

Report this publication

Statistics

Seen <100 times