Affordable Access

deepdyve-link
Publisher Website

The piglet as a model for B cell and immune system development.

Authors
  • Butler, J E1
  • Lager, K M
  • Splichal, I
  • Francis, D
  • Kacskovics, I
  • Sinkora, M
  • Wertz, N
  • Sun, J
  • Zhao, Y
  • Brown, W R
  • DeWald, R
  • Dierks, S
  • Muyldermans, S
  • Lunney, J K
  • McCray, P B
  • Rogers, C S
  • Welsh, M J
  • Navarro, P
  • Klobasa, F
  • Habe, F
  • And 1 more
  • 1 Department of Microbiology, University of Iowa, Iowa City, IA, United States. [email protected] , (United States)
Type
Published Article
Journal
Veterinary Immunology and Immunopathology
Publisher
Elsevier
Publication Date
Mar 15, 2009
Volume
128
Issue
1-3
Pages
147–170
Identifiers
DOI: 10.1016/j.vetimm.2008.10.321
PMID: 19056129
Source
Medline
Language
English
License
Unknown

Abstract

The ability to identify factors responsible for disease in all species depends on the ability to separate those factors which are environmental from those that are intrinsic. This is particularly important for studies on the development of the adaptive immune response of neonates. Studies on laboratory rodents or primates have been ambiguous because neither the effect of environmental nor maternal factors on the newborn can be controlled in mammals that: (i) transmit potential maternal immunoregulatory factors in utero and (ii) are altricial and cannot be reared after birth without their mothers. Employing the newborn piglet model can address each of these concerns. However, it comes at the price of having first to characterize the immune system of swine and its development. This review focuses on the porcine B cell system, especially on the methods used for its characterization in fetal studies and neonatal piglets. Understanding these procedures is important in the interpretation of the data obtained. Studies on neonatal piglets have (a) provided valuable information on the development of the adaptive immune system, (b) lead to important advances in evolutionary biology, (c) aided our understanding of passive immunity and (d) provided opportunities to use swine to address specific issues in veterinary and biomedical research and immunotherapy. This review summarizes the history of the development of the piglet as a model for antibody repertoire development, thus providing a framework to guide future investigators.

Report this publication

Statistics

Seen <100 times