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The Gammaherpesvirus Chemokine Binding Protein Binds to the N Terminus of CXCL8†

Authors
  • Louise M. C. Webb
  • Ian Clark-Lewis
  • Antonio Alcami
Publisher
American Society for Microbiology
Publication Date
Aug 01, 2003
Source
PMC
Keywords
Disciplines
  • Biology
License
Unknown

Abstract

Viruses encode proteins that disrupt chemokine responses. The murine gammaherpesvirus 68 gene M3 encodes a chemokine binding protein (vCKBP-3) which has no sequence similarity to chemokine receptors but inhibits chemokine receptor binding and activity. We have used a panel of CXCL8 analogs to identify the structural requirements for CXCL8 to bind to vCKBP-3 in a scintillation proximity assay. Our data suggest that vCKBP-3 acts by mimicking the binding of chemokine receptors to CXCL8.

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