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The effect of simulated obstructive apnea and hypopnea on aortic diameter and BP.

Authors
  • Stöwhas, Anne-Christin1
  • Namdar, Mehdi2
  • Biaggi, Patric2
  • Russi, Erich W3
  • Bloch, Konrad E3
  • Stradling, John R4
  • Kohler, Malcolm5
  • 1 Sleep Disorders Center and Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland. , (Switzerland)
  • 2 Division of Cardiology, University Hospital of Zurich, Zurich, Switzerland. , (Switzerland)
  • 3 Sleep Disorders Center and Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland; Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland. , (Switzerland)
  • 4 Oxford Center for Respiratory Medicine, Churchill Hospital, Oxford, England.
  • 5 Sleep Disorders Center and Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland; Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland. Electronic address: [email protected] , (Switzerland)
Type
Published Article
Journal
CHEST Journal
Publisher
Elsevier
Publication Date
September 2011
Volume
140
Issue
3
Pages
675–680
Identifiers
DOI: 10.1378/chest.10-2799
PMID: 21393398
Source
Medline
License
Unknown

Abstract

Simulated obstructive hypopnea/apnea and central apnea induced considerable changes in BP, and obstructive hypopnea was associated with an increase in proximal aortic diameter. Further studies are needed to investigate effects of apnea and hypopnea on transmural aortic pressure and aortic diameter to define the role of OSA in the pathogenesis of aortic dilatation.

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