The effect of hypertensive disorders in pregnancy on small for gestational age and stillbirth: a population based study

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The effect of hypertensive disorders in pregnancy on small for gestational age and stillbirth: a population based study

Publisher
BioMed Central
Publication Date
Aug 06, 2004
Source
PMC
Keywords
Disciplines
  • Biology
  • Ecology
License
Unknown

Abstract

1471-2393-4-17.fm ral ss BioMed CentBMC Pregnancy and Childbirth Open AcceResearch article The effect of hypertensive disorders in pregnancy on small for gestational age and stillbirth: a population based study Victoria M Allen*1, KS Joseph2, Kellie E Murphy3, Laura A Magee4 and Arne Ohlsson5 Address: 1Department of Obstetrics and Gynaecology, Dalhousie University, Halifax, Nova Scotia, Canada, 2Perinatal Epidemiology Research Unit, Department of Obstetrics and Gynaecology and of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada, 3Department of Obstetrics and Gynaecology, University of Toronto, Toronto, Ontario, Canada, 4Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada and 5Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada Email: Victoria M Allen* - [email protected]; KS Joseph - [email protected]; Kellie E Murphy - [email protected]; Laura A Magee - [email protected]; Arne Ohlsson - [email protected] * Corresponding author Abstract Background: Hypertensive disorders in pregnancy are leading causes of maternal, fetal and neonatal morbidity and mortality worldwide. However, studies attempting to quantify the effect of hypertension on adverse perinatal outcomes have been mostly conducted in tertiary centres. This population-based study explored the frequency of hypertensive disorders in pregnancy and the associated increase in small for gestational age (SGA) and stillbirth. Methods: We used information on all pregnant women and births, in the Canadian province of Nova Scotia, between 1988 and 2000. Pregnancies were excluded if delivery occurred < 20 weeks, if birthweight was < 500 grams, if there was a high-order multiple pregnancy (greater than twin gestation), or a major fetal anomaly. Results: The study population included 135,466 pregnancies. Of these, 7.7% had mild pregnancy- induced hypertension (PIH), 1.3% had severe PIH, 0.2% had HELLP (hemolysis, elevated liver enzymes, low

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