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The Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) trial

Authors
  • Eric J Eichhorn
  • Michael R Bristow
Publisher
BioMed Central
Publication Date
Jan 01, 2001
Source
PMC
Keywords
License
Unknown

Abstract

Previous trials (Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure [MERIT-HF], Cardiac Insufficiency Bisoprolol Study [CIBIS] II) have demonstrated a mortality benefit of β-adrenergic blockade in patients with mild to moderate heart failure. The recent Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) trial has extended these results to a more advanced patient population. This trial did not, however, include patients who could not reach compensation, patients with far advanced heart failure symptoms, or a significant number of black patients. Future studies of β-blockade may focus on these patients or patients with asymptomatic left ventricular dysfunction.

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