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The binding of the Fc fragment of guinea-pig cytophilic antibody to peritoneal macrophages

Authors
  • F. Y. Liew
Publication Date
May 01, 1971
Source
PMC
Keywords
License
Unknown

Abstract

Using radioactivity assays and radioautography, it has been confirmed that the majority of the guinea-pig anti-BSA cytophilic antibodies are found in the γ2 IgG fraction. The cytophilic activity was directly demonstrated to be present in the Fc portion of the IgG molecule. Furthermore, the Fc portion quantitatively accounts for the cytophilic activity of the whole IgG molecule.

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