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The 3' noncoding region of beta-globin mRNA is not essential for in vitro translation.

Authors
  • M N Kronenberg
  • B E Roberts
  • A Efstratiadis
Publication Date
Jan 01, 1979
Source
PMC
Keywords
License
Unknown

Abstract

Rabbit beta globin DNA sequence, excised from plasmid pbetaG1, directs in vitro synthesis of beta-globin in a transcription-translation cell-free system, even after specific elimination of the entire 3'-noncoding region. A DNA restriction fragment carrying this 3' noncoding region and hybridized to globin mRNA cannot arrest the cell-free translation of beta-globin mRNA.

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