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β-Thalassemia hijacking ineffective erythropoietin and iron overload: Two case reports and a review of literature.

Authors
  • Byatnal, Amit
  • Byatnal, Aditi A
  • Parvathi Devi, M K
  • Badriramkrishna, B
Type
Published Article
Journal
Journal of natural science, biology, and medicine
Publication Date
Jul 01, 2014
Volume
5
Issue
2
Pages
456–459
Identifiers
DOI: 10.4103/0976-9668.136245
PMID: 25097435
Source
Medline
Keywords
License
Unknown

Abstract

Thalassemia is a rare, complex disease, representing a group of disorders of hemoglobin synthesis that are characterized by reduced synthesis of either the alpha-globin or β-globin chains of the hemoglobin molecule. Defective synthesis of β-globin resulting from a variety of molecular defects causes β-thalassemia. Thalassemia is an autosomal recessive disorder, which requires prompt diagnosis and an appropriate treatment. Thorough clinical, radiographic and laboratory assessment helps in diagnosing thalassemia and any other hematological disorder. Here, two cases of β-thalassemia showing distinct features are presented and the importance of detailed work-up of the cases has been highlighted.

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