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Thalamic glutamate/glutamine in restless legs syndrome: increased and related to disturbed sleep.

Authors
  • Allen, Richard P1
  • Barker, Peter B
  • Horská, Alena
  • Earley, Christopher J
  • 1 Department of Neurology, Johns Hopkins University, Baltimore, MD, USA. [email protected]
Type
Published Article
Journal
Neurology
Publisher
Ovid Technologies (Wolters Kluwer) - American Academy of Neurology
Publication Date
May 28, 2013
Volume
80
Issue
22
Pages
2028–2034
Identifiers
DOI: 10.1212/WNL.0b013e318294b3f6
PMID: 23624560
Source
Medline
License
Unknown

Abstract

The primary findings introduce 2 new related dimensions to RLS: abnormalities in a major nondopaminergic neurologic system and the arousal disturbance of sleep. The strong relation of the arousal sleep disturbance to glutamate and the lack of relation to the PLMS motor features of RLS contrasts with the reverse for dopamine of a limited relation to arousal sleep disturbance but strong relation to PLMS. Understanding this dichotomy and the interaction of these 2 differing systems may be important for understanding RLS neurobiology and developing better treatments for RLS.

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