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Th17 lineage commitment and HIV-1 pathogenesis.

Authors
  • Ancuta, Petronela1
  • Monteiro, Patricia
  • Sekaly, Rafick-Pierre
  • 1 Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Saint-Luc Hospital, Pavillon Edouard Asselin, 264 Blvd. René-Lévesque East, Montréal, Québec, Canada. [email protected] , (Canada)
Type
Published Article
Journal
Current opinion in HIV and AIDS
Publication Date
Mar 01, 2010
Volume
5
Issue
2
Pages
158–165
Identifiers
DOI: 10.1097/COH.0b013e3283364733
PMID: 20543594
Source
Medline
License
Unknown

Abstract

The discovery of human Th17 lineage revised our thinking about CD4 T-cell heterogeneity and plasticity in the context of HIV pathogenesis. The present review highlights unsolved mysteries around the genetic control of differentiation and tissue-specific specialization of human Th17 cells. Systems biology studies are now required to provide a global view of transcriptional changes in Th17 subsets and mucosal tissues and to shed light on molecular mechanisms of Th17 depletion in HIV infection, with the final goal to identify new strategies to improve mucosal immunity in infected individuals.

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