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TGR5 contributes to glucoregulatory improvements after vertical sleeve gastrectomy in mice.

Authors
  • McGavigan, Anne K1
  • Garibay, Darline1
  • Henseler, Zachariah M2, 3
  • Chen, Jack1
  • Bettaieb, Ahmed4
  • Haj, Fawaz G4
  • Ley, Ruth E2, 3
  • Chouinard, Michael L5
  • Cummings, Bethany P1
  • 1 Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
  • 2 Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA.
  • 3 Department of Microbiology, Cornell University, Ithaca, New York, USA.
  • 4 Department of Nutrition, University of California, Davis, Davis, California, USA.
  • 5 Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana, USA. , (India)
Type
Published Article
Journal
Gut
Publisher
BMJ
Publication Date
Feb 01, 2017
Volume
66
Issue
2
Pages
226–234
Identifiers
DOI: 10.1136/gutjnl-2015-309871
PMID: 26511794
Source
Medline
Keywords
License
Unknown

Abstract

These results suggest that TGR5 contributes to the glucoregulatory benefits of VSG surgery by promoting metabolically favourable shifts in the circulating bile acid pool.

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