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TGF-β gives an air of exclusivity to alveolar macrophages

Authors
  • Lambrecht, Bart
Publication Date
Jan 01, 2017
Source
Ghent University Institutional Archive
Keywords
Language
English
License
Unknown
External links

Abstract

Tissue-resident macrophages shape the development and homeostasis of the organs that they colonize. Yu et al. (2017) demonstrate that, unique to the lung, the instructive cytokine TGF-beta collaborates with GM-CSF to induce the master transcription factor PPAR gamma to drive alveolar macrophage differentiation and maintenance early in life.

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