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Tetrahydrobiopterin prevents platelet-activating factor-induced intestinal hypoperfusion and necrosis: Role of neuronal nitric oxide synthase.

Authors
  • Qu, Xiao-Wu
  • Thaete, Larry G
  • Rozenfeld, Ranna A
  • Zhu, Yaqin
  • De Plaen, Isabelle G
  • Caplan, Michael S
  • Hsueh, Wei
Type
Published Article
Journal
Critical Care Medicine
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
May 01, 2005
Volume
33
Issue
5
Pages
1050–1056
Identifiers
PMID: 15891335
Source
Medline
License
Unknown

Abstract

We conclude that nNOS selectively regulates intestinal perfusion. Tetrahydrobiopterin prevents PAF-induced intestinal injury, probably by stabilizing nNOS and maintaining intestinal perfusion.

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